The present study describes a simple, accurate, precise and cost effective UV-Spectrophotometric method for the estimation of Ritonavir, an anti-HIV drug, in bulk and pharmaceutical dosage form. The drug was first dissolved in isopropyl alcohol and final volume wasmadeup with distilled water. The λmax or the absorption maxima of the drug was found to be 245nm. A linear response was observed in the range of 10- 60μg/ml with a regression coefficient of 0.999. The method was then validated for different parameters as per the ICH (International Conference for Harmonization) guidelines. This method can be used for the determination of Ritonavir in quality control of formulation without interference of the excipients.
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